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Anti-DMPK (N-term) Antibody
Catalog #: 102-13244
Rabbit Anti-Human DMPK (N-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q09013 |
| Gene Id | 1760 |
| Gene Symbols | DMPK |
| Protein Name / Synonyms | DMPK (N-term) |
| Clonality | Polyclonal |
| Preparation | This DMPK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 amino acids from the N-terminal region of human DMPK. |
| Concentration (lot specific) | 0.500 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Specificity
Other Names
DMPK; DM1PK; MDPK; Myotonin-protein kinase; DM-kinase; DM1 protein kinase; Myotonic dystrophy protein kinase
NCBI Accession #
NP_001075029.1;NP_001075031.1;NP_001075032.1;NP_004400.4
Other Accession #
NP_001075029.1; NP_001075031.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
69385
Recommended Dilutions
WB: 1:1000
 | DMPK Antibody (N-term) (Cat# 102-13244) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the DMPK antibody detected the DMPK protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.