Anti-DMTF1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9Y222
Gene Id	9988
Gene Symbols	DMTF1
Protein Name / Synonyms	DMTF1 (C-term)
Clonality	Polyclonal
Preparation	This DMTF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-616 amino acids from the C-terminal region of human DMTF1.
Concentration (lot specific)	0.300 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Specificity

Predicted Reactivity

Mouse, Rat

Other Names

DMTF1; DMP1; Cyclin-D-binding Myb-like transcription factor 1; Cyclin-D-interacting Myb-like protein 1

NCBI Accession #

NP_001135798.1;NP_001135799.1;NP_066968.3

Other Accession #

Q66HG1; Q8CE22; NP_001135798.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

84471

Recommended Dilutions

WB: 1:1000

DMTF1 Antibody (C-term) (Cat# 102-13496) western blot analysis in U937 cell line lysates (35ug/lane).This demonstrates the DMTF1 antibody detected the DMTF1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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