Rabbit Anti-Human Dnmt3a (N-term R46) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q9Y6K1 |
| Gene Id | 1788 |
| Gene Symbols | DNMT3A |
| Protein Name / Synonyms | Dnmt3a (N-term R46) |
| Clonality | Polyclonal |
| Preparation | This Dnmt3a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-61 amino acids from the N-terminal region of human Dnmt3a. |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Research Area | Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3a is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
Specificity
Predicted Reactivity
Mouse, Rat
Other Names
DNMT3A; DNA (cytosine-5)-methyltransferase 3A; DNA methyltransferase HsaIIIA
NCBI Accession #
NP_072046.2;NP_715640.2;NP_783328.1;NP_783329.1
Other Accession #
Q1LZ53; O88508
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
101858
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | Western blot analysis of anti-Dnmt3a Antibody (N-term R46) (Cat# 102-10625) in Jurkat cell line lysates (35ug/lane). Dnmt3a(arrow) was detected using the purified Pab. |
 | Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with Dnmt3a antibody (N-term R46) (Cat# 102-10625), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.