Anti-Drosophila AMPK alpha-1/2 Antibody

Product Description

Specifications

Size	0.1 mg
Estimated Lead Time	1-2 weeks
Species	Drosophila
Host Species	Mouse
Protein Name / Synonyms	AMPK alpha-1/2
Concentration (lot specific)	1.0mg/ml
Recommended Applications	Immunohistology - Frozen, ELISA (dilution: 1/100, 1/1000), Immunofluorescence, Immunoprecipitation, Western Blotting
Research Area	AMPK Signaling, Energy Metabolism
Shipping Type	Blue ice
Storage	-20°C

Description

This product detects a band of approximately 63kDa in rat brain cell lysates.

Specificity

This product recognizes both the alpha 1 and the alpha 2 isoforms of AMP-activated protein kinase (AMPK). AMPK is a highly conserved heterotrimeric protein kinase found in all eukaryotes. The heterotrimeric complex exists as multiple isoforms and consists of a catalytic alpha subunit, which is stabilised by non-catalytic regulatory beta- and gamma- subunits. AMPK plays a vital role in maintaining cellular energy homeostasis and is activated by rising levels of AMP under conditions of hypoxia, ischemia, exercise, low glucose levels.

AMPK may play an important role in the control of type 2 diabetes and metabolic syndromes. Recent studies suggest that AMPK functions as a suppressor of cell proliferation of both malignant and normal cells.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:

Purified IgG - liquid

Formulation:

Phosphate buffered saline

Format Type:

Purified

Preparation

Immunogen:

29 amino acid peptide within the N-terminal catalytic domain of Drosophila AMPK alpha.

Preservative:

0.09%

Sodium Azide (NaN₃)

Expiration:

12 months from the date of shipment when stored properly.