Rabbit Anti-Human DSCR1 (C-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P53805 |
| Gene Id | 1827 |
| Gene Symbols | RCAN1 |
| Protein Name / Synonyms | DSCR1 (C-term) |
| Clonality | Polyclonal |
| Preparation | This DSCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-252 amino acids from the C-terminal region of human DSCR1. |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
DSCR1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. The gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of DSCR1 may lead to neurofibrillary tangles such as those associated with Alzheimer disease.
Specificity
Predicted Reactivity
Mouse, Rat, Bovine, Hamster
Other Names
RCAN1; ADAPT78; CSP1; DSC1; DSCR1; Calcipressin-1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; Regulator of calcineurin 1
NCBI Accession #
NP_004405.3;NP_981962.1;NP_981963.1
Other Accession #
Q6IN33; Q9JHG6; O35847; Q3ZBP4; Q7Z555
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
28079
Recommended Dilutions
WB: 1:1000
 | Endothelial cell lysate transferred to membrane was incubated with primary antibody at a 1:500 dilution in 2% BSA in TBST at 4deg C overnight. Data courtesy of Dr. Katherine Healey, NWCRF Institute, School of Biological Sciences, University of Wales Bangor. |
 | The anti-DSCR1 Pab (Cat# 102-16746) is used in Western blot to detect DSCR1 in endothelial tissue lysate. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.