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Anti-DUSP6 (Center) Antibody
Catalog #: 102-17879
Rabbit Anti-Human DUSP6 (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q16828 |
| Gene Id | 1848 |
| Gene Symbols | DUSP6 |
| Protein Name / Synonyms | DUSP6 (Center) |
| Clonality | Polyclonal |
| Preparation | This DUSP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-89 amino acids from the Central region of human DUSP6. |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting, IF |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for the DUSP6 gene.
Specificity
Predicted Reactivity
Bovine
Other Names
DUSP6; MKP3; PYST1; Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; Mitogen-activated protein kinase phosphatase 3
NCBI Accession #
NP_001937.2;NP_073143.2
Other Accession #
Q2KJ36; NP_001937
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
42320
Recommended Dilutions
IF: 1:10-50; WB: 1:1000
 | Confocal immunofluorescent analysis of DUSP6 Antibody (Center) (Cat# 102-17879) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). |
 | The anti-DUSP6 Pab (Cat# 102-17879) is used in Western blot to detect DUSP6 in HeLa cell lysate. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.