Anti-DVL1 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O14640
Gene Id	1855
Gene Symbols	DVL1
Protein Name / Synonyms	DVL1 (Center)
Clonality	Polyclonal
Preparation	This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-470 amino acids from the Central region of human DVL1.
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	IF, IHC-P, Western Blotting
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.

Specificity

Predicted Reactivity

Mouse, Rat

Other Names

DVL1; Segment polarity protein dishevelled homolog DVL-1; DSH homolog 1

NCBI Accession #

NP_004412.2

Other Accession #

P54792; Q9WVB9; P51141; NP_004412.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

75187

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50; IF: 1:10-50

	DVL1 Antibody (Center) (Cat# 102-11509) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the DVL1 antibody detected the DVL1 protein (arrow).
	DVL1 Antibdy (Center) (Cat# 102-11509)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DVL1 Antibdy (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
	Confocal immunofluorescent analysis of DVL1 Antibody (Center) (Cat# 102-11509) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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