Anti-Endorphin-B Antibody

beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC). (Note, POMC also gives rise to other peptide hormones, including ACTH ( Adrenocorticotropic hormone ), as well alpha- and ?-MSH ( Melanocyte-Stimulating Hormone ), resulting from intracellular processing by internal enzymes known as prohormone convertases.) beta-endorphin is found in neurons of the hypothalamus, as well as the pituitary gland. It is an agonist of the opioid receptors, with evidence suggesting it serves as the endogenous ligand of the µ-opioid receptor, the same receptor to which the chemicals extracted from opium, such as morphine, have their analgesic and addictive effects (indeed, the µ-opioid receptor was named based on its most renowned ligand, morphine).

The antibody can specifically bind to human Beta-Endorphin. Cross reactivity with mouse or rat Endorphin-B was not tested.

Store at 4°C if intended for use within one month, otherwise, store at -20°C to -80°C. The lyophilized antibody is stable for at least 18 months after the date of receipt when stored at -20°C to -80°C. After reconstitution, it can also be aliquoted and stored frozen at -20°C to -80°C in a manual defrost freezer for at least 6 months without detectable loss of activity. Upon reconstitution, the antibody can also be stored for 30 days at 4°C. Please avoid freeze-thaw cycles, as this will lower the activity of the antibody.