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Anti-Endorphin-B Antibody, Biotinylated
Catalog #: 130-10077B-50
Rabbit anti-Endorphin-B Biotinylated Antibody, 50 ug
Product Description
Specifications
| Size | 50 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P01189 |
| Gene Id | 5443 |
| Gene Symbols | POMC |
| Clonality | Polyclonal |
| Immunogen | Immunogen was synthetic peptide derived from human Beta-Endorphin. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum followed by Protein A/G affinity chromatography. |
| Isotype | IgG |
| Recommended Applications | ELISA (recommended work dilution= 1:160, 000) |
| Reconstitution | A separate vial of dilution buffer is provided for reconstitution. The antibody is supplied lyophilized, originally containing PBS, without preservative stabilizers (e.g. sodium azide). The final amount is indicated on the shipping vial. |
| Research Area | Cancer |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC). (Note, POMC also gives rise to other peptide hormones, including ACTH ( Adrenocorticotropic hormone ), as well alpha- and ?-MSH ( Melanocyte-Stimulating Hormone ), resulting from intracellular processing by internal enzymes known as prohormone convertases.) beta-endorphin is found in neurons of the hypothalamus, as well as the pituitary gland. It is an agonist of the opioid receptors, with evidence suggesting it serves as the endogenous ligand of the µ-opioid receptor, the same receptor to which the chemicals extracted from opium, such as morphine, have their analgesic and addictive effects (indeed, the µ-opioid receptor was named based on its most renowned ligand, morphine).
Storage / Stability
The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.
Specificity
The antibody can specifically bind to human Beta-Endorphin. Cross reactivity with mouse or rat Endorphin-B was not tested.
References
- Batistaki C, et al.. (2008) Effect of exogenous catecholamines on tumor necrosis factor alpha, interleukin-6, interleukin-10 and beta-endorphin levels following severe trauma. Vascul Pharmacol. 48(2-3):85-91.
- Nicolas P and Li CH. (1985) Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia. Proc Natl Acad Sci U S A. 82(10):3178-81.
Expiration:
12 months from the date of shipment when stored properly.