Anti-ERBB3 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P21860
Gene Id	2065
Gene Symbols	ERBB3
Protein Name / Synonyms	Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3, HER3
Clonality	Polyclonal
Clone	RB01467
Isotype	Kappa, Rabbit
Recommended Applications	Western Blotting, IHC-P, FC
Research Area	Cardiovascular Disease, Cancer, Tyrosine Kinase Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

ErbB3, a member of the EGF receptor family, binds and is activated by neuregulins and NTAK. It potentially forms a heterodimer with each of the other ERBB receptors. This protein is predominantly expressed in epithelial tissues and brain. The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins. Ligand-binding may increase phosphorylation on tyrosine residues and promote its association with the p85 subunit of phosphatidylinositol 3-kinase ErbB3 is overexpressed in a subset of human mammary tumors.

Other Information

NCBI Accession #

NP_001005915.1;NP_001973.2

Antigen Type

Synthetic Peptide

Format

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Calculated Molecular Weight (Da)

148098

Antigen Source

Human

Images

WB (1:1000)

Western blot analysis of anti-ErbB3 Pab (Cat. #102-27342) in mouse brain lysate. ErbB3 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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