Rabbit Anti-Human FADD(Center) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q13158 |
| Gene Id | 8772 |
| Gene Symbols | FADD |
| Protein Name / Synonyms | FADD(Center) |
| Clonality | Polyclonal |
| Preparation | This FADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the Central region of human FADD. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Apoptosis, Cardiovascular Disease, Cancer, Autoimmune Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Specificity
Other Names
FADD; MORT1; Protein FADD; Mediator of receptor induced toxicity; FAS-associated death domain protein; FAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein
NCBI Accession #
NP_003815.1
Other Accession #
NP_003815.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
23279
Recommended Dilutions
WB: 1:1000
 | FADD Antibody (Center) (Cat# 102-14347) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the FADD antibody detected the FADD protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.