Anti-FGFR1 (Y154) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P11362
Gene Id	2260
Gene Symbols	FGFR1
Protein Name / Synonyms	FGFR1 (Y154)
Clonality	Polyclonal
Preparation	This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-161 amino acids from human FGFR1.
Concentration (lot specific)	0.260 mg/ml
Recommended Applications	Western Blotting
Research Area	Angiogenesis, Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome.

Specificity

Other Names

FGFR1; BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR; Fibroblast growth factor receptor 1; Basic fibroblast growth factor receptor 1; Fms-like tyrosine kinase 2; N-sam; Proto-oncogene c-Fgr; CD_antigen=CD331; Flags: Precursor

NCBI Accession #

NP_001167534.1;NP_001167535.1;NP_001167536.1;NP_001167537.1;NP_001167538.1;NP_056934.2;NP_075593.1;NP_075594.1;NP_075598.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

91868

Recommended Dilutions

WB: 1:1000

	Western blot analysis of anti-FGFR1 Antibody (Y154) (Cat# 102-17495) in K562 cell line lysates (35ug/lane).FGFR1 (arrow) was detected using the purified Pab.
	Western blot analysis of FGFR1 (arrow) using rabbit polyclonal FGFR1-pY154 (Cat# 102-17495). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR1 gene (Lane 2).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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