Anti-FGFR3 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P22607
Gene Id	2261
Gene Symbols	FGFR3
Protein Name / Synonyms	FGFR3 (C-term)
Clonality	Polyclonal
Preparation	This FGFR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 776-806 amino acids from the C-terminal region of human FGFR3.
Concentration (lot specific)	1.360 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

FGFR3 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.

Specificity

Other Names

FGFR3; JTK4; Fibroblast growth factor receptor 3; CD_antigen=CD333; Flags: Precursor

NCBI Accession #

NP_000133.1;NP_001156685.1;NP_075254.1

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

87710

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	Western blot analysis of anti-FGFR3 Pab (Cat# 102-17501) in Jurkat cell lysate. FGFR3 (Arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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