Rabbit Anti-Human FKBP1A (C-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P62942 |
| Gene Id | 2280 |
| Gene Symbols | FKBP1A |
| Protein Name / Synonyms | FKBP1A (C-term) |
| Clonality | Polyclonal |
| Preparation | This FKBP1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the C-terminal region of human FKBP1A. |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting, IHC-P, FC |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
Specificity
Predicted Reactivity
Bovine, Rabbit
Other Names
FKBP1A; FKBP1; FKBP12; Peptidyl-prolyl cis-trans isomerase FKBP1A; 12 kDa FK506-binding protein; Calstabin-1; FK506-binding protein 1A; Immunophilin FKBP12; Rotamase
NCBI Accession #
NP_000792.1;NP_463460.1
Other Accession #
P62943; P18203
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
11951
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100; FC: 1:10-50
 | Western blot analysis of FKBP1A antibody (C-term) (Cat# 102-17604) in Jurkat cell line lysates (35ug/lane). FKBP1A (arrow) was detected using the purified Pab. |
 | FKBP1A Antibody (C-term) (Cat# 102-17604) IHC analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FKBP1A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
 | Western blot analysis of FKBP1A (arrow) using rabbit polyclonal FKBP1A Antibody (C-term) (Cat# 102-17604). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FKBP1A gene. |
 | FKBP1A Antibody (C-term) (Cat# 102-17604) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.