The far upstream element-binding proteins FUBP, FUBP2, and FUBP3 comprise a family of single-strand DNA-binding proteins that possess all of the general features of more conventional transcription factors. The FUBPs each bind to a single sequence-specific strand of the far upstream element (FUSE; originally identified upstream of c-myc), and each possesses potent activation domains when fused to the GAL4 DNA-binding domain and assayed by transient transfection. These proteins have also been reported to bind RNA and participate in various steps of RNA processing, transport or catabolism.

HUMAN

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