Anti-FZD6 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O60353
Gene Id	8323
Gene Symbols	FZD6
Protein Name / Synonyms	FZD6 (Center)
Clonality	Polyclonal
Preparation	This FZD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-520 amino acids from the Central region of human FZD6.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Research Area	Wnt-beta-Catenin Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants.

Specificity

Predicted Reactivity

Mouse

Other Names

FZD6; Frizzled-6

NCBI Accession #

NP_001158087.1;NP_001158088.1;NP_003497.2

Other Accession #

Q61089; NP_001158087.1; NP_003497.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

79292

Recommended Dilutions

WB: 1:1000

FZD6 Antibody (Center) (Cat# 102-10895) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the FZD6 antibody detected the FZD6 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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