Anti-FZR1 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9UM11
Gene Id	51343
Gene Symbols	FZR1
Protein Name / Synonyms	FZR1 (N-term)
Clonality	Polyclonal
Preparation	This FZR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-81 amino acids from the N-terminal region of human FZR1.
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Specificity

Predicted Reactivity

Mouse

Other Names

FZR1; CDH1; FYR; FZR; KIAA1242; Fizzy-related protein homolog; CDC20-like protein 1; Cdh1/Hct1 homolog

NCBI Accession #

NP_001129669.1;NP_001129670.1;NP_057347.2

Other Accession #

Q9R1K5; NP_057347.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

55179

Recommended Dilutions

WB: 1:1000

FZR1 Antibody (N-term) (Cat# 102-14097) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the FZR1 antibody detected the FZR1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

Featured Products