Rabbit Anti-GCLC (Center) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | P48506 |
| Gene Id | 2729 |
| Gene Symbols | GCLC |
| Protein Name / Synonyms | GCLC (Center) |
| Clonality | Polyclonal |
| Preparation | This GCLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-315 amino acids from the Central region of human GCLC. |
| Concentration (lot specific) | 0.400 mg/ml |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
Specificity
Predicted Reactivity
Rat
Other Names
GCLC; GLCL; GLCLC; Glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase
NCBI Accession #
NP_001184044.1;NP_001489.1
Other Accession #
P19468; P97494; NP_001489.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
72766
Recommended Dilutions
WB: 1:1000
 | GCLC Antibody (Center) (Cat# 102-13864) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the GCLC antibody detected the GCLC protein (arrow). |
 | GCLC Antibody (Center) (Cat# 102-13864) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the GCLC antibody detected the GCLC protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.