Rabbit Anti-Germinal Center Kinase (GCK/MAP4K2) (Center) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | Q12851 |
| Gene Id | 5871 |
| Gene Symbols | MAP4K2 |
| Protein Name / Synonyms | Germinal Center Kinase (GCK/MAP4K2) (Center) |
| Clonality | Polyclonal |
| Preparation | This Germinal Center Kinase (GCK/MAP4K2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-319 amino acids from the Central region of human Germinal Center Kinase (GCK/MAP4K2). |
| Concentration (lot specific) | 1.420 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Research Area | Phosphorylation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.
Specificity
Other Names
MAP4K2; GCK; RAB8IP; Mitogen-activated protein kinase kinase kinase kinase 2; B lymphocyte serine/threonine-protein kinase; Germinal center kinase; MAPK/ERK kinase kinase kinase 2; Rab8-interacting protein
NCBI Accession #
NP_004570.2
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
91556
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100
 | The anti-MAP4K2 Pab (Cat# 102-17106) is used in Western blot to detect MAP4K2 in mouse skeletal muscle tissue lysate. |
 | Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.