Anti-GJB6 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O95452
Gene Id	10804
Gene Symbols	GJB6
Protein Name / Synonyms	GJB6 (N-term)
Clonality	Polyclonal
Preparation	This GJB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-117 amino acids from the N-terminal region of human GJB6.
Concentration (lot specific)	1.100 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. I Mutations in GJB2 are associated with genetically derived hearing impairments, including autosomal dominant, bilateral, middle to high frequency hearing loss.

Specificity

Other Names

GJB6; Gap junction beta-6 protein; Connexin-30

NCBI Accession #

NP_001103689.1;NP_001103690.1;NP_001103691.1;NP_006774.2

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

30387

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	Western blot analysis of GJB6 (arrow) using rabbit polyclonal GJB6 Antibody (N-term) (Cat# 102-12791). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GJB6gene (Lane 2) (Origene Technologies).
	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
	Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with GJB6 Antibody (N-term) (Cat# 102-12791), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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