Anti-GPR17 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q13304
Gene Id	2840
Gene Symbols	GPR17
Protein Name / Synonyms	GPR17 (Center)
Clonality	Polyclonal
Preparation	This GPR17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-258 amino acids from the Central region of human GPR17.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P, FC
Research Area	Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Members of the G protein coupled receptor (GPCR) superfamily contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The organization of the GPR17 gene differs from that of many other GPCRs in that the open reading frame is distributed on 2 exons; an additional exon contains the 5 prime untranslated region. Human GPR17 is expressed as 2.3 and 6.3 kb mRNAs exclusively in brain. The 2 transcripts appear to represent alternatively polyadenylated variants. Based on protein sequence homology and the conservation of certain key residues, GPR17 appears to be closely related to the P2Y family of GPCRs. There are two nemed isoforms.

Specificity

Other Names

GPR17; Uracil nucleotide/cysteinyl leukotriene receptor; G-protein coupled receptor 17; P2Y-like receptor; R12

NCBI Accession #

NP_001154887.1;NP_001154888.1;NP_001154889.1;NP_005282.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

40989

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100; FC: 1:10-50

	Western blot analysis of GPR17 Antibody (Center) (Cat# 102-18418) in MDA-MB435 cell line lysates (35ug/lane). GPR17 (arrow) was detected using the purified Pab.
	GPR17 Antibody (Center) (Cat# 102-18418) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GPR17 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
	GPR17 Antibody (Center) (Cat# 102-18418) flow cytometric analysis of MDA-MB435 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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