Anti-GPR56 Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Mouse
Accession Number	Q9Y653
Gene Id	9289
Gene Symbols	ADGRG1
Protein Name / Synonyms	G-protein coupled receptor 56, Protein TM7XN1, GPR56 N-terminal fragment, GPR56 NT, GPR56(N), GPR56 extracellular subunit, GPR56 subunit alpha, GPR56 C-terminal fragment, GPR56 CT, GPR56(C), GPR56 seven-transmembrane subunit, GPR56 7TM, GPR56 subunit beta, GPR56, TM7LN4, TM7XN1
Clonality	Monoclonal
Clone	1443CT377.65.29
Isotype	Kappa, IgG1
Recommended Applications	Western Blotting
Research Area	Angiogenesis
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis.

Other Information

Calculated Molecular Weight (Da)

77738

Antigen Source

Human

Images

WB (1:2000)

Western blot analysis of lysate from Hela cell line, using GPR56(Cat. #102-20124). 102-20124 was diluted at 1:2000. A goat anti-mouse IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20?g.

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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