Anti-GRIA4 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P48058
Gene Id	2893
Gene Symbols	GRIA4
Protein Name / Synonyms	GRIA4 (Center)
Clonality	Polyclonal
Preparation	This GRIA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the Central region of human GRIA4.
Concentration (lot specific)	0.410 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq].

Specificity

Predicted Reactivity

Rat, Monkey

Other Names

GRIA4; GLUR4; Glutamate receptor 4; AMPA-selective glutamate receptor 4; GluR-D; Glutamate receptor ionotropic, AMPA 4

NCBI Accession #

NP_000820.3;NP_001070711.2;NP_001070712.1;NP_001106283.1

Other Accession #

P19493; Q9Z2W8; Q38PU5; NP_000820.3

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

100871

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	GRIA4 Antibody (Center) (Cat# 102-11799) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the GRIA4 antibody detected the GRIA4 protein (arrow).
	GRIA4 Antibody (Center) (Cat# 102-11799) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the GRIA4 antibody detected the GRIA4 protein (arrow).
	GRIA4 Antibody (Center) (Cat# 102-11799)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GRIA4 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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