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Anti-GRP Antibody
Catalog #: 130-10093
Rabbit Anti-Human GRP Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg, 200 µg, 500 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Accession Number | P07492 |
| Gene Id | 2922 |
| Gene Symbols | GRP |
| Clonality | Polyclonal |
| Immunogen | Immunogen was synthetic peptide derived from human GRP. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum by Protein A/G affinity chromatography. |
| Immunogen Sequence | CVPLPAGGGTVLTKMYPRGNHWAVGHLM |
| Recommended Applications | ELISA (recommended work dilution= 1: 80, 000) |
| Reconstitution | Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile water to a final concentration of 1 mg/ml. |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms.
Specificity
The antibody binds to human GRP, and no cross reactivity with unrelated antigens in ELISA. Cross reactivity with mouse or rat GRP was not tested.
Storage
Store at 4°C if intended for use within one month, otherwise, store at -20°C to -80°C. The lyophilized antibody is stable for at least 18 months after the date of receipt when stored at -20°C to -80°C. After reconstitution, it can be aliquoted and stored frozen at -20°C to -80°C in a manual defrost freezer for at least 6 months without detectable loss of activity. Upon reconstitution, the antibody can also be stored for 1 month at 4°C. Please avoid freeze-thaw cycles, as this will lower the activity of the antibody.
Related Products
RayBio® Gastrin Releasing Peptide (GRP) EIA Kit for Serum, Plasma, Culture Supernatant and Cell Lysates (cat# EIA-GRP-1 )
References
- Spindel, E.R. et al. (1986) "Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides." Proc. Natl. Acad. Sci. U.S.A. 83:19-23
- Lebacq-Verheyden A.-M. et al. (1988) "Posttranslational processing of endogenous and of baculovirus-expressed human gastrin-releasing peptide precursor."Mol. Cell. Biol. 8:3129-3135
Expiration:
12 months from the date of shipment when stored properly.