Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

WB 1:500 - 1:2000; IHC 1:50 - 1:200; IF 1:50 - 1:200

A synthetic peptide corresponding to a sequence within amino acids 550-650 of human HDAC5 (NP_005465.2).

Unmodified

Store at -20°. Avoid freeze / thaw cycles.