Anti-HFE2 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q6ZVN8
Gene Id	148738
Gene Symbols	HFE2
Protein Name / Synonyms	HFE2 (C-term)
Clonality	Polyclonal
Preparation	This HFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-338 amino acids from the C-terminal region of human HFE2.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, FC
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Specificity

Predicted Reactivity

Mouse, Rat

Other Names

HFE2; HJV; RGMC; Hemojuvelin; Hemochromatosis type 2 protein; RGM domain family member C

NCBI Accession #

NP_660320.3;NP_973733.1;NP_998817.1;NP_998818.1

Other Accession #

Q8N7M5; Q7TQ32

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

45080

Recommended Dilutions

WB: 1:1000; FC: 1:10-50

	Western blot analysis of HFE2 Antibody (C-term) (Cat# 102-18359) in HepG2 cell line lysates (35ug/lane). HFE2 (arrow) was detected using the purified Pab.
	HFE2 Antibody (C-term) (Cat# 102-18359) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

Featured Products