Anti-HLA-B Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Accession Number	P03989
Gene Symbols	HLA-B
Protein Name / Synonyms	HLA-B
Clonality	Monoclonal
Preparation	This HLA-B antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 62-90 amino acids from human HLA-B.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Research Area	Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

Specificity

Other Names

HLA-B; HLAB; HLA class I histocompatibility antigen, B-27 alpha chain; MHC class I antigen B*27

Other Accession #

P30490; P30488; P30487; P30486; P30485; P30483; P30481; P30479; Q04826; P18463; P30464; P30461; NP_005505.2

Format

Type

Mouse Monoclonal Antibody (Mab)

Calculated Molecular Weight (Da)

40428

Recommended Dilutions

WB: 1:100-250

HLA-B Antibody(Cat# 102-10341) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the HLA-B antibody detected the HLA-B protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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