Anti-HP1 alpha Antibody

Product Description

Specifications

Size	100 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Mouse
Accession Number	P45973
Gene Id	23468
Gene Symbols	CBX5
Protein Name / Synonyms	Antigen p25;Cbx 5;Cbx5;CBX5_HUMAN;CG8409;Chromobox homolog 5 (Drosophila HP1 alph
Clonality	Monoclonal
Recommended Applications	Western Blotting, ICC, IHC
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Other Information

Antigen Type

Recombinant Protein

Images

WB (1:1000)

Western blot detection of HP1 alpha in MCF7,293T,HelaNE,3T3,C6,COS7 and Mouse brain lysates and using HP1 alpha mouse mAb (1:1000 diluted).Predicted band size: 22KDa.Observed band size: 22KDa

ICC (1:300)

Immunocytochemistry stain of Hela using HP1 alpha mouse mAb (1:300).

IHC (1:100)

Immunohistochemical analysis of paraffin-embedded human breast carcinoma with HP1 alpha mouse mAb (3G2-H10-A6, 1:400 diluted ),showing nuclear localization.A high pressure mediated antigen retrieval step was performed in citrat buffer(pH6.0).

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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