Anti-HRX (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q03164
Gene Id	4297
Gene Symbols	KMT2A
Protein Name / Synonyms	HRX (C-term)
Clonality	Polyclonal
Preparation	This HRX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3879-3908 amino acids from the C-terminal region of human HRX.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	FC, IHC-P
Research Area	Apoptosis
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. Tse et al. (1995) characterized 2 t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21, AF1Q, in 2 infants with acute myelomonocytic leukemia. In one of these patients, the derivative chromosome 11 represented an in-frame fusion of the N-terminal portion of the MLL gene to the complete AF1Q open reading frame, whereas the derivative chromosome 1 did not give rise to an open reading frame. This observation suggested that the N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23.

Specificity

Other Names

MLL; ALL1; CXXC7; HRX; HTRX; KMT2A; MLL1; TRX1; Histone-lysine N-methyltransferase MLL; ALL-1; CXXC-type zinc finger protein 7; Lysine N-methyltransferase 2A; Trithorax-like protein; Zinc finger protein HRX; MLL cleavage product N320; N-terminal cleavage product of 320 kDa; MLL cleavage product C180; C-terminal cleavage product of 180 kDa

NCBI Accession #

NP_001184033.1;NP_005924.2

Other Accession #

NP_005924

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

431764

Recommended Dilutions

FC: 1:10-50; IHC: 1:50-100

	HRX Antibody (C-term) (Cat# 102-11007) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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