Anti-HSPC142 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9NWV8
Gene Id	29086
Gene Symbols	BABAM1
Protein Name / Synonyms	HSPC142 (N-term)
Clonality	Polyclonal
Preparation	This HSPC142 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-37 amino acids from the N-terminal region of human HSPC142.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component

Specificity

Predicted Reactivity

Zebrafish, Bovine

Other Names

BABAM1; C19orf62; MERIT40; NBA1; BRISC and BRCA1-A complex member 1; Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex

NCBI Accession #

NP_001028721.1;NP_054892.2

Other Accession #

Q6AXK4; Q08E57; NP_054892

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

36560

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	HSPC142 Antibody (N-term) (Cat# 102-17923) western blot analysis in T47D cell line lysates (15ug/lane).This demonstrates the HSPC142 antibody detected the HSPC142 protein (arrow).
	HSPC142 Antibody (N-term) (Cat# 102-17923) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HSPC142 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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