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Anti-Human HLA-DR, DP, DQ Antibody, Biotinylated
Catalog #: 136-01128
Human HLA-DR, DP, DQ Biotinylated Antibody [clone: IVA12], monoclonal Mouse IgG1. Validated for flow cytometry.
Product Description
Specifications
| Size | 100 µg, 500 µg |
| Estimated Lead Time | 3-5 business days |
| Species | Human |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Clone | IVA12 |
| Conjugation | Biotin |
| Preparation | The antibody was purified by affinity chromatography, and conjugated with biotin. |
| Isotype | IgG1 |
| Format | Liquid |
| Concentration (lot specific) | 0.5 mg/mL |
| Buffers | PBS, pH 7.2-7.4, 0.2% BSA, 0.1% sodium azide |
| Recommended Applications | Flow Cytometry |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | 4°C |
Description
Product Features
- Serum-free media used for cell culture of hybridomas to minimize bovine antibody contamination
- Gentle elution at pH 4.0 to minimize antibody degradation
- Protein A, G & L affinity purification
- High purity
Description
MHC class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells. Human leukocyte antigens (HLAs) corresponding to MHC class II are HLA-DP, HLA-DM, HLA-DOA, HLA-DOB, HLA-DQ, and HLA-DR. MHC cass II interacts with T cell receoptor complex and present antigenic peptide to activate CD4 T cells. These cells are important in initiating immune responses. This antibody recognizes HLA-DR, DP, and DQ, which are the three main types of HLA class II molecules.