Anti-HYAL1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q12794
Gene Id	3373
Gene Symbols	HYAL1
Protein Name / Synonyms	HYAL1 (C-term)
Clonality	Polyclonal
Preparation	This HYAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human HYAL1.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Angiogenesis, Cancer, Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.

Specificity

Other Names

HYAL1; LUCA1; Hyaluronidase-1; Hyaluronoglucosaminidase-1; Lung carcinoma protein 1

NCBI Accession #

NP_149349.2;NP_695013.1;NP_695014.1;NP_695015.1;NP_695017.1

Other Accession #

NP_695013.1; NP_695017.1; NP_009296.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

48368

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	HYAL1 Antibody (C-term) (Cat# 102-12704) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the HYAL1 antibody detected the HYAL1 protein (arrow).
	HYAL1 Antibody (C-term) (102-12704)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HYAL1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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