3607 Parkway Ln Ste 200 Norcross, Georgia 30092
www.RayBiotech.com | info@raybiotech.com
770-729-2992 | +1-888-494-8555
ISO 13485:2016 cGMP
Anti-IGF1 Receptor (IGF1R) (N-term) Antibody
Catalog #: 102-17513
Rabbit Anti-Human IGF1 Receptor (IGF1R) (N-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P08069 |
| Gene Id | 3480 |
| Gene Symbols | IGF1R |
| Protein Name / Synonyms | IGF1 Receptor (IGF1R) (N-term) |
| Clonality | Polyclonal |
| Preparation | This IGF1 Receptor (IGF1R) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-51 amino acids from the N-terminal region of human IGF1 Receptor (IGF1R). |
| Concentration (lot specific) | 1.640 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The IGF1R receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.
Specificity
Predicted Reactivity
Mouse, Rat
Other Names
IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; CD_antigen=CD221; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain
NCBI Accession #
NP_000866.1
Other Accession #
P24062; Q60751
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
154793
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100
 | Western blot analysis of anti-IGF1R Antibody (N-term) (Cat# 102-17513) in SK-BR-3 cell line lysates (35ug/lane). IGF1R (arrow) was detected using the purified Pab. |
 | Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.