Anti-IGHD (N-term) (Ascites) Antibody

Product Description

Specifications

Size	0.1 mL
Estimated Lead Time	1-2 weeks
Species	Human
Accession Number	P01880
Gene Symbols	IGHD
Protein Name / Synonyms	IGHD (N-term) (Ascites)
Clonality	Monoclonal
Preparation	This IGHD antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 37-64 amino acids from the N-terminal region of human IGHD.
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.

Specificity

Other Names

IGHD; Ig delta chain C region

Format

Type

Mouse Monoclonal Antibody (Mab)

Calculated Molecular Weight (Da)

42254

Recommended Dilutions

WB: 1:100-800

IGHD Antibody (N-term)(Ascites)(Cat# 102-10364) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the IGHD antibody detected the IGHD protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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