Anti-IKB alpha (IKBA) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P25963
Gene Id	4792
Gene Symbols	NFKBIA
Protein Name / Synonyms	IKB alpha (IKBA)
Clonality	Polyclonal
Preparation	This IKB alpha (IKBA) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from human IKB alpha (IKBA).
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Research Area	Cancer, Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).

Specificity

Other Names

NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; Major histocompatibility complex enhancer-binding protein MAD3

NCBI Accession #

NP_065390.1

Other Accession #

NP_065390

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

35609

Recommended Dilutions

WB: 1:1000

The anti-IKB-alpha N-term Pab (Cat# 102-15041) is used in Western blot to detect IKB-alpha in Jurkat cell lysate.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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