Anti-IKK beta Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Accession Number	O14920
Gene Id	3551
Gene Symbols	IKBKB
Protein Name / Synonyms	IKK beta
Clonality	Monoclonal
Preparation	This IKK beta antibody was raised using purified His-tagged recombinant full length human IKK beta.
Concentration (lot specific)	1.070 mg/ml
Recommended Applications	Western Blotting
Research Area	Cancer, Inflammation, NFkB Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).

Specificity

Other Names

IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B kinase 2; Nuclear factor NF-kappa-B inhibitor kinase beta

NCBI Accession #

NP_001177649.1;NP_001229707.1;NP_001547.1

Format

Type

Purified Mouse Monoclonal Antibody (Mab)

Calculated Molecular Weight (Da)

86564

Recommended Dilutions

WB: 1:100-500

The anti-IKKbeta Mab (Cat# 102-10511) is used in Western blot to detect IKKbeta in SK-BR3 cell lysate.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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