Anti-IKZF3 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q9UKT9
Gene Id	22806
Gene Symbols	IKZF3
Protein Name / Synonyms	IKZF3 (Center)
Clonality	Polyclonal
Preparation	This IKZF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the Central region of human IKZF3.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.

Specificity

Predicted Reactivity

Bovine

Other Names

IKZF3; ZNFN1A3; Zinc finger protein Aiolos; Ikaros family zinc finger protein 3

NCBI Accession #

NP_001244337.1;NP_001244338.1;NP_001244339.1;NP_001244340.1;NP_001244341.1;NP_001244342.1;NP_001244343.1;NP_036613.2;NP_899051.1;NP_899052.1;NP_899053.1;NP_899054.1;NP_899055.1

Other Accession #

A2VDW9; NP_036613.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

58023

Recommended Dilutions

WB: 1:1000

	IKZF3 Antibody (Center) (Cat# 102-16550) western blot analysis in mouse liver tissue lysates (15ug/lane).This demonstrates the IKZF3 antibody detected IKZF3 protein (arrow).
	Western blot analysis of extracts from MM cells, treated with DMSO or lenalidomide, using rabbit polyclonal IKZF3 Antibody (Center) (Cat# 102-16550).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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