Anti-JAB1 Antibody

Product Description

Specifications

Size	100 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse, Rat
Host Species	Rabbit
Accession Number	Q9UNS2
Gene Id	8533
Gene Symbols	COPS3
Protein Name / Synonyms	COP9 signalosome complex subunit 3, SGN3, Signalosome subunit 3, JAB1-containing signalosome subunit 3, COPS3, CSN3
Clonality	Polyclonal
Recommended Applications	Western Blotting, IF
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Other Information

Antigen Type

Synthetic Peptide

Images

WB (1:1000)

Western blot analysis of lysates from HT-29,Hela cell line (from left to right),using JAB1 Antibody(102-25633). 102-25633 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.

WB ( 1:1000)

Western blot analysis of extracts from A549 cells (Lane 1) and HepG2 cells (Lane 2), using JAB1 Antibody.

IF (1:100)

Immunofluorescence analysis of HeLa cells, treated with Forskolin (40nM, 30mins), using JAB1 antibody (#102-25633)

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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