Anti-KAT1 (HAT1) (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O14929
Gene Id	8520
Gene Symbols	HAT1
Protein Name / Synonyms	KAT1 (HAT1) (C-term)
Clonality	Polyclonal
Preparation	This KAT1 (HAT1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-419 amino acids from the C-terminal region of human KAT1 (HAT1).
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Histone acetylation, particularly of histone H4, has been proposed to play an important role in replication-dependent nucleosome assembly. The HAT1 protein contains D, A, and B motifs, which are present in many N-acetyltransferases, including those that acetylate substrates other than histones. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46. The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. HAT1 may play a role in telomeric silencing.

Specificity

Predicted Reactivity

Mouse, Rat

Other Names

HAT1; KAT1; Histone acetyltransferase type B catalytic subunit; Histone acetyltransferase 1

NCBI Accession #

NP_003633.1

Other Accession #

Q5M939; Q8BY71

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

49513

Recommended Dilutions

WB: 1:1000

Western blot analysis of hHAT1-E404 (Cat# 102-10804) in 293, HepG2, Jurkat cell line lysates (35ug/lane). HAT1 (arrow) was detected using the purified Pab.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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