Anti-KDELR1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P24390
Gene Id	10945
Gene Symbols	KDELR1
Protein Name / Synonyms	KDELR1 (C-term)
Clonality	Polyclonal
Preparation	This KDELR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-211 amino acids from the C-terminal region of human KDELR1.
Concentration (lot specific)	0.470 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.

Specificity

Predicted Reactivity

Mouse, Rat, Zebrafish, Bovine, Chicken, Xenopus

Other Names

KDELR1; ERD2.1; ER lumen protein retaining receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; Putative MAPK-activating protein PM23

NCBI Accession #

NP_006792.1

Other Accession #

O42580; Q8R1L4; O43731; Q7ZXS5; Q5U305; Q9CQM2; P33947; Q6PEH1; Q5ZKX9; Q2KJ37; Q569A6; Q99JH8; P33946; Q68ES4; Q6PAB8; NP_006792.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

24542

Recommended Dilutions

WB: 1:1000

KDELR1 Antibody (C-term) (Cat# 102-14151) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the KDELR1 antibody detected the KDELR1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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