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Anti-Ketohexokinase (KHK) (C-term) Antibody
Catalog #: 102-17108
Rabbit Anti-Ketohexokinase (KHK) (C-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | P50053 |
| Gene Id | 3795 |
| Gene Symbols | KHK |
| Protein Name / Synonyms | Ketohexokinase (KHK) (C-term) |
| Clonality | Polyclonal |
| Preparation | This Ketohexokinase (KHK) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-281 amino acids from the C-terminal region of human Ketohexokinase (KHK). |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Energy Metabolism, Glycolysis & Lipid Metabolism |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Ketohexokinase (KHK), or fructokinase, catalyzes conversion of fructose to fructose-1-phosphate. Splice variant 1 is the highly active form found in liver, renal cortex, and small intestine, while splice variant 2 is the lower activity form found in most other tissues. KHK, like glucokinase (GCK) and glucokinase regulator (GCKR), is present in both liver and pancreatic islets. The inhibition of GCK by GCKR is blocked by binding of fructose-1-phosphate to GCKR. The chromosomal proximity of the metabolically connected GCKR and KHK genes has a genetic linkage in type 2 diabetes. Fructosuria, or hepatic fructokinase deficiency, is a benign, asymptomatic defect of intermediary metabolism associated with heterozygosity for G50R and A43T mutations in KHK.
Specificity
Other Names
KHK; Ketohexokinase; Hepatic fructokinase
NCBI Accession #
NP_000212.1;NP_006479.1
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
32730
Recommended Dilutions
WB: 1:1000
 | The anti-KHK Pab (Cat# 102-17108) is used in Western blot to detect KHK in mouse kidney tissue lysate. |
 | Western blot analysis of KHK (arrow) using rabbit polyclonal Ketohexokinase (KHK) Antibody (C-term) (Cat# 102-17108). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the KHK gene (Lane 2) (Origene Technologies). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.