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Anti-KIDINS220 (C-term) Antibody
Catalog #: 102-12912
Rabbit Anti-Human KIDINS220 (C-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q9ULH0 |
| Gene Id | 57498 |
| Gene Symbols | KIDINS220 |
| Protein Name / Synonyms | KIDINS220 (C-term) |
| Clonality | Polyclonal |
| Preparation | This KIDINS220 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1518-1547 amino acids from the C-terminal region of human KIDINS220. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
KIDINS220 promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin-and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
Specificity
Other Names
KIDINS220; ARMS; KIAA1250; Kinase D-interacting substrate of 220 kDa; Ankyrin repeat-rich membrane-spanning protein
NCBI Accession #
NP_065789.1
Other Accession #
NP_065789.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
196542
Recommended Dilutions
WB: 1:1000
 | KIDINS220 Antibody (C-term) (Cat# 102-12912) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the KIDINS220 antibody detected the KIDINS220 protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.