Anti-KIR2DS3 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q14952
Gene Id	3808
Gene Symbols	KIR2DS3
Protein Name / Synonyms	KIR2DS3 (C-term)
Clonality	Polyclonal
Preparation	This KIR2DS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-295 amino acids from the C-terminal region of human KIR2DS3.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P, FC
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Specificity

Other Names

KIR2DS3; NKAT7; Killer cell immunoglobulin-like receptor 2DS3; MHC class I NK cell receptor; Natural killer-associated transcript 7

NCBI Accession #

NP_036445.1

Other Accession #

Q8N743; Q14953; P43628; NP_036445.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

33717

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100; FC: 1:10-50

	KIR2DS3 Antibody (C-term) (Cat# 102-16576) western blot analysis in HL-60 cell line lysates (15ug/lane).This demonstrates the KIR2DS3 antibody detected the KIR2DS3 protein (arrow).
	KIR2DS3 Antibody (C-term) (Cat# 102-16576) immunohistochemistry analysis in formalin fixed and paraffin embedded human spleen tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the KIR2DS3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
	KIR2DS3 Antibody (C-term) (Cat# 102-16576) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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