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Anti-Lambda Light Chain Antibody Cocktail
Catalog #: 188-10109
Mouse anti-Human Lambda Light Chain Antibody Cocktail
Product Description
Specifications
| Size | 20 µg, 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Other species not known |
| Host Species | Mouse |
| Accession Number | P01701|P0CG04 |
| Gene Id | 3535 |
| Gene Symbols | IGLV1-51,IGLC1 |
| Protein Name / Synonyms | Immunoglobulin lambda variable 1-51 (Ig lambda chain V-I region BL2) (Ig lambda chain V-I region EPS) (Ig lambda chain V-I region NEW) (Ig lambda chain V-I region NIG-64), Immunoglobulin lambda constant 1 (Ig lambda chain C region MGC) (Ig lambda-1 chain C region) |
| Immunogen | Purified human Ig (LcN-2 and ICO-106) was used as the immunogen for this Lambda light chain antibody cocktail. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 0.2 mg/ml in 1X PBS (pH 7.4) with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Recommended Applications | FACS: 0.5-1ug/million cells IF: 0.5-1ug/ml Western Blotting: 0.5-1.0ug/ml IHC (FFPE): 0.5-1.0ug/ml for 30 minutes at RT Prediluted format: incubate for 30 min at RT (2) |
| Domain / Region / Terminus | Cell surface, cytoplasmic and secreted |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
This antibody cocktail is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. In general, the ratio of Kappa to Lambda is 3:1. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Lambda light chain antibody is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Storage
Store the Lambda Light Chain antibody cocktail at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.