Anti-LDB2 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O43679
Gene Id	9079
Gene Symbols	LDB2
Protein Name / Synonyms	LDB2 (C-term)
Clonality	Polyclonal
Preparation	This LDB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-342 amino acids from the C-terminal region of human LDB2.
Concentration (lot specific)	0.400 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins (summarized by Semina et al., 1998 [PubMed 9799849]). These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes (Jurata and Gill, 1997 [PubMed 9315627]). The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 (Bach et al., 1997 [PubMed 9192866]) and Clim2/Lbd1/Nli (Agulnick et al., 1996 [PubMed 8918878]; Jurata et al., 1996 [PubMed 8876198]; Bach et al., 1997 [PubMed 9192866]) and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.

Specificity

Predicted Reactivity

Mouse, Chicken

Other Names

LDB2; CLIM1; LIM domain-binding protein 2; Carboxyl-terminal LIM domain-binding protein 1; LIM domain-binding factor CLIM1

NCBI Accession #

NP_001124306.1;NP_001281.1

Other Accession #

O55203; Q9W676; NP_001124306.1; NP_001281.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

42793

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	LDB2 Antibody (C-term) (Cat# 102-12459) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the LDB2 antibody detected the LDB2 protein (arrow).
	LDB2 Antibody (C-term) (102-12459)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LDB2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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