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Anti-LDLR (Center) Antibody
Catalog #: 102-18095
Rabbit Anti-LDLR (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | P01130 |
| Gene Id | 3949 |
| Gene Symbols | LDLR |
| Protein Name / Synonyms | LDLR (Center) |
| Clonality | Polyclonal |
| Preparation | This LDLR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human LDLR. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting, FC |
| Research Area | Cardiovascular Disease, Inflammation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place.
Specificity
Predicted Reactivity
Rat, Hamster, Pig, Rabbit, Xenopus
Other Names
LDLR; Low-density lipoprotein receptor
NCBI Accession #
NP_000518.1;NP_001182727.1;NP_001182728.1;NP_001182729.1;NP_001182732.1
Other Accession #
P35952; P20063; Q28832; P35951; P35950; Q99088; Q99087
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
95376
Recommended Dilutions
WB: 1:1000; FC: 1:10-50
 | Western blot analysis of LDLR Antibody (Center) (Cat# 102-18095) in mouse lung tissue lysates (35ug/lane). LDLR (arrow) was detected using the purified Pab. |
 | LDLR Antibody (Center) (Cat# 102-18095) FC analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.