Anti-LGMN (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q99538
Gene Id	5641
Gene Symbols	LGMN
Protein Name / Synonyms	LGMN (N-term)
Clonality	Polyclonal
Preparation	This LGMN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the N-terminal region of human LGMN.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.

Specificity

Predicted Reactivity

Monkey

Other Names

LGMN; PRSC1; Legumain; Asparaginyl endopeptidase; Protease, cysteine 1

NCBI Accession #

NP_001008530.1;NP_005597.3

Other Accession #

Q4R4T8; NP_005597.3

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

49411

Recommended Dilutions

WB: 1:1000

LGMN Antibody (N-term) (Cat# 102-14491) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the LGMN antibody detected the LGMN protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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