Anti-LIN7B (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q9HAP6
Gene Id	64130
Gene Symbols	LIN7B
Protein Name / Synonyms	LIN7B (N-term)
Clonality	Polyclonal
Preparation	This LIN7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human LIN7B.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).

Specificity

Predicted Reactivity

Rat, Bovine

Other Names

LIN7B; MALS2; VELI2; Protein lin-7 homolog B; Mammalian lin-seven protein 2; Vertebrate lin-7 homolog 2

NCBI Accession #

NP_071448.1

Other Accession #

Q9Z252; O88951; Q2KIB6; NP_071448.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

22896

Recommended Dilutions

WB: 1:1000

	LIN7B Antibody (N-term) (Cat# 102-14415) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the LIN7B antibody detected the LIN7B protein (arrow).
	LIN7B Antibody (N-term) (Cat# 102-14415) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the LIN7B antibody detected the LIN7B protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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