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Anti-M JMJD3 (Center) Antibody
Catalog #: 102-10601
Rabbit Anti-M JMJD3 (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | Q5NCY0 |
| Gene Id | 216850 |
| Gene Symbols | KDM6B |
| Protein Name / Synonyms | M JMJD3 (Center) |
| Clonality | Polyclonal |
| Preparation | This Mouse JMJD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 954-987 amino acids from the Central region of mouse JMJD3. |
| Concentration (lot specific) | 2.000 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Inflammation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Specificity
Other Names
Kdm6b; Jmjd3; Kiaa0346; Lysine-specific demethylase 6B; JmjC domain-containing protein 3; Jumonji domain-containing protein 3
NCBI Accession #
NP_001017426.1
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
176355
Recommended Dilutions
WB: 1:1000
 | Western blot analysis of anti-JMJD3 Center Pab (102-10601) in Hela cell line lysates. JMJD3 Center(arrow) was detected using the purified Pab. |
Antigen Source
MOUSE
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.