Anti-MAP3K7IP3 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q8N5C8
Gene Id	257397
Gene Symbols	TAB3
Protein Name / Synonyms	MAP3K7IP3 (N-term)
Clonality	Polyclonal
Preparation	This MAP3K7IP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MAP3K7IP3.
Concentration (lot specific)	0.350 mg/ml
Recommended Applications	Western Blotting
Research Area	Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Specificity

Predicted Reactivity

Mouse

Other Names

TAB3; MAP3K7IP3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NF-kappa-B-activating protein 1; TAK1-binding protein 3; TGF-beta-activated kinase 1-binding protein 3

NCBI Accession #

NP_690000.2

Other Accession #

Q571K4; NP_690000.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

78683

Recommended Dilutions

WB: 1:1000

MAP3K7IP3 Antibody (N-term) (Cat# 102-13258) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the MAP3K7IP3 antibody detected the MAP3K7IP3 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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